Pharmascience #Preparations_for_the_treatment_of_infections #Antiviral_agents #HEALTH_CARE
Product description
Valtsik tablets are indicated for:
- Treatment of herpes zoster (herpes zoster).
- Treating infections of the skin and mucous membranes caused by the herpes simplex virus, including primary and recurrent genital herpes.
- Treating herpes labialis (lip fever).
- Preventive treatment (suppression) of recurrent infections of the skin and mucous membranes caused by the herpes simplex virus, including genital herpes.
- Reducing the transmission of genital herpes virus to a healthy partner when using the preparation as suppressive therapy in combination with safe sex.
- Prevention of cytomegalovirus infection and disease after organ transplantation.
Compound
Active ingredient: valaciclovir;
1 tablet contains valaciclovir hydrochloride 556 mg in terms of valacyclovir 100% anhydrous substance 500 mg;
Excipients: microcrystalline cellulose (101), povidone, anhydrous colloidal silicon dioxide, crospovidone, magnesium stearate;
Shell composition: Sepifilm 050 (methyl hydroxypropyl cellulose, microcrystalline cellulose, acetylated (or ester acetates) mono- and diglycerides)), kandurin.
Contraindications
Hypersensitivity to valacyclovir, acyclovir, or any component of the preparation.
Mode of application
Treatment of herpes zoster: for adults, appoint 1000 mg (2 tablets) 3 times a day for 7 days.
Treatment of infections caused by the herpes simplex virus. Patients with normal immunity (adults): 500 mg (1 tablet) of the preparation 2 times a day.
Application features
Pregnant
Can be used only when the potential benefit from treatment to the mother outweighs the potential risk to the fetus.
Children
It is used for children over 12 years of age for the prevention of cytomegalovirus infection and disease.
Drivers
Carefully.
Overdose
Symptoms Overdose of valacyclovir has reported the development of acute renal failure and neurological symptoms, including confusion, hallucinations, agitation, decreased mental capacity and coma. Nausea and vomiting may have been observed. To prevent unintentional overdose, use caution. Many cases of overdose were associated with the use of the preparation for the treatment of patients with renal insufficiency and elderly patients, for whom the dose was not reduced accordingly.
Treatment. Patients need to be closely monitored for toxicity. Hemodialysis significantly accelerates the elimination of acyclovir from the blood and therefore it can be considered the optimal treatment for symptomatic overdose.
Side effects
Among the more serious adverse reactions were reports of thrombotic thrombocytopenic purpura / hemolytic uremic syndrome, acute renal failure, and neurological disorders.
Interaction
No clinically significant forms of interaction were identified.
Patients who receive higher doses of the preparation (4 g or more per day) should be careful when prescribing concomitantly with preparations that compete with acyclovir for the elimination route, as this can lead to an increase in plasma levels of one or both preparations and their metabolites ... With simultaneous use with mycophenolate mofetil (an immunosuppressive preparation used after organ transplantation), the plasma level of acyclovir and the inactive metabolite of mycophenolate mofetil increases.
You should also be careful (with monitoring changes in renal function) while prescribing high doses of the preparation (4 g or more) and other preparations that affect renal function (for example, cyclosporine, tacrolimus).
Storage conditions
Store at a temperature not exceeding 30 ° C out of the reach of children.
Shelf life is 4 years.
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