MERCK #Non_sex_hormones #Thyroid #HEALTH_CARE
Product description
Eutirox is a hormone preparation for systemic use. Levothyroxine sodium.
Eutirox 25-200 mcg
- treatment of benign euthyroid goiter;
- prevention of relapses after surgical treatment of euthyroid goiter, depending on the level of the hormone in the postoperative period;
- as replacement therapy for hypothyroidism;
- suppressive therapy for thyroid cancer.
Eutirox 25-100 mcg
- as an adjunct preparation for antithyroid therapy in hyperthyroidism.
Eutirox 100/150/200 mcg
- as a diagnostic tool for a thyroid suppression test.
Compound
active substance: sodium levothyroxine;
1 tablet contains levothyroxine sodium 25 mcg or 50 mcg or 75 mcg or 100 mcg or 125 mcg or 150 mcg;
other constituents: mannitol (E 421); corn starch; gelatin; sodium croscarmellose; anhydrous citric acid, magnesium stearate.
Contraindications
Increased individual sensitivity to the components of the preparation.
Insufficiency of the adrenal glands, pituitary insufficiency, thyrotoxicosis, which have not been treated.
Acute myocardial infarction, acute myocarditis, acute pancarditis.
Combined therapy with levothyroxine and antithyroid preparations during pregnancy is not prescribed.
Mode of application
Recommended doses (levothyroxine sodium):
- Treatment of benign euthyroid goiter - 75-200 mcg / day;
- Prevention of relapses after surgical treatment of euthyroid goiter - 75-200 mcg / day;
In the replacement therapy of hypothyroidism in adults:
- the initial dose is 25-50 mcg / day;
- maintenance dose - 100-200 mcg / day;
In the replacement therapy of hypothyroidism in children:
- the initial dose is 12.5-50 mcg / day;
- maintenance dose - 100-150 mcg / m2 body surface;
- As an adjuvant during antithyroid therapy of hyperthyroidism - 50-100 mcg / day;
- Suppressive therapy for thyroid cancer - 150-300 mcg / day;
As a diagnostic tool for a thyroid suppression test:
- two weeks before the test - two tablets per day;
- one week before the test - two tablets per day.
Application features
Levothyroxine therapy in patients at risk of developing psychotic disorders should be started with low doses of the preparation, gradually increasing the dosage at the beginning of therapy. It is recommended to observe the patient's condition. In the case of the development of psychotic disorders, the possibility of adjusting the dose of levothyroxine should be considered.
Pregnant
There are no data on teratogenicity and / or fetotoxicity when taking the preparation in the recommended therapeutic doses. Taking very high doses of levothyroxine during pregnancy can negatively affect the fetus and the child's postnatal development.
Children
Possible use for children
Drivers
There is no data on the possible effect on the ability to drive vehicles or work with complex mechanisms. However, since levothyroxine in its action is identical to the natural thyroid hormone, the effect of Eutirox on the reaction rate when driving vehicles or other mechanisms is not expected.
Overdose
For symptoms manifested as pronounced beta-sympathomimetic effects, such as tachycardia, anxiety, nervous agitation, hyperkinesia, beta blockers are prescribed. If the dose is significantly exceeded, plasmapheresis is recommended.
Side effects
Symptoms: from the cardiovascular system: cardiac arrhythmias (atrial fibrillation, extrasystole), tachycardia, angina pectoris, palpitations, hot flashes; from the nervous system: headaches, insomnia, anxiety, brain pseudotumor, tremor; from the digestive tract: vomiting, diarrhea, weight loss; on the part of the skin and the musculoskeletal system: increased sweating, muscle weakness and cramps; general disorders: increased body temperature; disorders of the menstrual cycle.
Storage conditions
Store at a temperature not exceeding 25 C in its original packaging. Keep out of the reach of children.
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