BAUSCH & LOMB #Eyes #Eye_drops #HEALTH_CARE
Product description
Luxfen (Luxphen)
eye drops - to treat open-angle glaucoma, decrease in
intraocular pressure. The preparation can be used as a monotherapeutic agent by
patients who have contraindications to the use of local beta-adrenoreceptor
blockers.
Luxfen eye drops - antiglaucoma
preparation. Brimonidine is a selective α 2 -adrenoreceptor agonist.
When instillation 0.2% solution of brimonidine, the
decrease in intraocular pressure is 10-12 mm Hg. The maximum effect is observed
after 2 hours, the duration of the action is 12 hours.
Brimonidine has a dual mechanism of action: it lowers
the intraocular pressure by decreasing the synthesis of the intraocular fluid
and enhancing the uveoscleral outflow.
Pharmacokinetics
Suction and distribution
When instillation of eye drops Cmax preparation in
blood plasma is achieved after 0.5-2.5 h. Binding to blood proteins with
topical application is 29%. The systemic absorption of brimonidine is slowed
down. After applying the preparation 2 times / day for 10 days, the
concentration of brimonidine in the plasma remains low (an average of 0.06 ng /
ml).
Metabolism and distribution
The preparation is metabolized primarily in the liver.
Brimonidine and its metabolites are excreted by the kidneys. T1 / 2 is about 2
hours.
Indications:
Open angle glaucoma, ophthalmic hypertension (in
monotherapy and in combination with other preparations that reduce intraocular
pressure).
Contraindications:
- Hypersensitivity to the components of the preparation;
- simultaneous therapy with monoamine oxidase
(MAO) inhibitors and tricyclic antidepressants;
- children's age up to 2 years;
- the
period of lactation.
With caution: when using the preparation in patients
with severe, unstable and uncontrolled form of cardiovascular disease, with
cerebral or coronary insufficiency, depression, orthostatic hypotension,
Raynaud's disease, obliterating thromboangiitis; if the liver or kidney
function is impaired; children age from 2 to 18 years.
Special instructions:
Before using the preparation, contact lenses should be
removed. The time interval between use of the preparation and the
re-installation of contact lenses should be at least 15 minutes.
Impact on the ability to drive vehicles and other
mechanisms that require increased concentration
The preparation can cause fatigue or drowsiness,
reduced vision, so during preparation treatment should refrain from driving
vehicles and servicing moving mechanisms.
Suggested Use:
Bury 1 drop of the preparation 2 times a day.
The duration of treatment is determined by the doctor.
Packaging:
- Comes in original packaging. Item is brand
new and unopened.
Storage:
- Keep away from direct sunlight.
- Keep locked and away from children.
- Store in dry place at room temperature.
- Do not exceed storage temperature higher
than 25 C
Important notice- the outer box design may vary before prior notice!
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