Doktor Willmar Schwabe GmbH & Ko.KG #The_nervous_system #Calming_silencing #HEALTH_CARE
Pharmacological properties
Pharmacodynamics. Lasea, which contains silexan® lavender oil, has antidepressant, anxiolytic and sedative effects after oral administration. In vitro studies have shown that silexan® interacts with tension-regulated calcium channels (voccs), mainly of the p / q-type, but the mechanism of action or the site of binding to calcium channels has not been elucidated. there are reports that lavender oil affects gamma receptors by potentiating gamma responses. linalool, the main component of lavender oil, interacts with glutamate receptors, inhibits glutamate uptake and release, and modulates gamma receptors.
Pharmacokinetics. After oral administration of 80 mg of Silexan® in a phase I study, 30 minutes after administration of the preparation, the concentration of the main component of the essential oil, linalool, is recorded at a level of 22 ng / ml. The concentration of linalool in blood plasma decreased within 5 hours after administration with an average area under the curve (AUC) of 33 ng · h / ml.
Indications
Treating mild to moderate anxiety disorders with symptoms such as nervous tension, irritability and anxiety.
Application
Adults and children over the age of 12: 1 capsule per day (equivalent to 80 mg of lavender oil).
The capsules should be taken without chewing, with a sufficient amount of liquid (preferably a glass of drinking water). The preparation Lasea is not recommended to be taken while lying down.
Contraindications
Hypersensitivity to lavender oil or any of the components of the preparation. age up to 12 years.
Side effects
From the gastrointestinal tract: often - gastrointestinal disorders (mainly belching).
On the part of the skin and subcutaneous tissues / immune system: often - allergic skin reactions.
Special instructions
Patients with rare hereditary fructose intolerance should not take Lasea.
Use during pregnancy and lactation. There are no clinical data on the use of lavender oil during pregnancy. The preparation Lasea is not recommended for use during pregnancy. The safety of use during breastfeeding has not yet been studied. It is not known whether the components of lavender oil or their metabolites pass into breast milk. During the period of breastfeeding, it is not recommended to use the preparation Lasea.
Children. Prescribed to children over the age of 12 years.
The ability to influence the reaction rate when driving or working with other mechanisms. Unknown.
Interactions
Unknown.
Overdose
Overdose cases have not been reported.
Storage conditions
At a temperature not exceeding 30 ° C, out of the reach of children.
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